Experimental Research on the Interactions between Selective COX-2 Inhibitors and Antidepressants

Objectives: The Porsolt test and the tail suspension test were performed on mice to investigate possible mood effects of parecoxib, and to assess the interactions between this agent and antidepressants belonging to two different classes. Materials and methods: In the Porsolt test, parecoxib was given in geometric progression doses (ratio 2), in order to assess the depressant/antidepressant effect, then parecoxib was given in the dose of 40 mg/kg body weight (bw), either alone or in association with amitriptyline 5 mg/kg bw in both tests, and in association with Corresponding author: Horia Pãunescu, Assistant Lecturer, PhD, MD 8th, Eroilor Sanitari Av., District 5, Bucharest e-mail: [email protected] Experimental Research on the Interactions between Selective COX-2 Inhibitors and Antidepressants